Session Index

Current super-resolution techniques are limited in deep-tissue, due to lack of optical-sectioning, or susceptibility to scattering/aberration. Here we propose plasmonic saturated excitation microscopy, which relies on less-affected temporal modulation into tissues, to provide bleaching-free and background-free imaging with three-fold resolution enhancement throughout the 200-μm working distance of an objective.

 

For performing spectroscopic measurement with sensing volume of picoliter, an optical fiber spectroscopic cell has been fabricated by using near-ultraviolet femtosecond laser. A novel optical measurement method devising aggregation of gold nanoparticles was established which enables to detect L-cysteine with detection sensitivity of 3.0×10^-15 mol by using the spectroscopic cell.

 

We present a multifunctional sensing array with gold nanowire-nanorod hybrid-nanostructures for dual detection of surface plasmon resonance and surface enhanced Raman scattering. The cost-effective nanostructures were made simply onto plastic films using hot-embossing nanoimprint lithography. The estimated SERS enhancement factor and SPR thickness sensitivity were 2.82×10^6 and 0.74 nm/nm, respectively.

 

We have used a label-free, high-resolution Supercontinuum laser based full-field optical coherence microscopy (FF-OCM) to visualize morphological changes of stomata and guard cells in plant leaves. Our results show a significant three dimensional morphological change in stomata and guard cell with varying concentrations of potassium chloride (KCl).

 

We use photoacoustic microscopy (PAM) to study lipopolysaccharide (LPS)-induced sepsis model in mice for the first time. Quantitative changes of four vessel structural parameters are monitored for 8 hours after the application of LPS with four different concentrations. The results suggest that PAM has potential for sepsis evaluation.

 

Accurate surgeries hold the key to good prognoses of brain tumors. An intraoperative optical intrinsic signal imaging is employed to distinguish lesions. The result shows vessels in tumor region have poor ability to provide oxygen.