Session Index

We have developed a high speed and long-wavelength swept-source optical coherence tomography (SS-OCT) imaging system with a 1.7 µm wavelength-swept laser. The 1.7 µm SS-OCT imaging technology exhibits potential for deep-tissue imaging where the light attenuation due to tissue scattering is reduced which might promote future various functional imaging applications.

 

Optical coherence tomography angiography (OCTA) can observe the structure of capillaries which is related to diseases. Therefore, we try to acquire better images by combining the system with correlation mapping method and Jones matrix calculation.

 

The inner ear is a small and sophisticated organ, mainly comprising the vestibular system and cochlea. In this study, we leverage the technology of swept-source optical coherence tomography to obtain the ex vivo image of the mouse cochlea for a better understanding of the cochlear architectures.

 

To image live Caenorhabditis elegans (C. elegans) requires imaging with optical sectioning. Typically, confocal microscopy is a standard system to be utilized for three-dimensional (3D) imaging; however, confocal needs time-consuming. Here, we report light sheet microscopy(LSM) to observe 3D images of a C. elegans with high resolution in real time.

 

In this study, characterization of micropatterns formed by shearing a droplet of DNA liquid crystal is presented. Experimental results suggest that the formation of pattern associated with induced forces in the process is governed by material and preparation conditions. Our results provide guidelines for DNA-templating fabrication and applications.

 

This study aims to evaluate attention levels under different lighting environments by brainwaves. Signals are processed by Hilbert-Huang transform for spectral powers in the alpha and beta bands. The receiver operating characteristic analysis is utilized to suggest candidates of attention index based on the classification accuracy of binary discrimination tasks.

 

Dishwashing detergent is widely used for cleaning dishes after eating. The detergent might be remained on the dishes cause of the impropriated dosage of detergent. This study provided a cost-efficient sensor, which can be embedded into the dishwasher, to determine the concentration of detergent by analyzing the transmission intensity variation.

 

In this study, we present a new route to surpass the diffraction limit in a label-free manner by pump-probe microscopy where one focal field at the 180 degree phase signal can be generated from the central region, and a 0 degree phase signal generated from the doughnut region.

 

Magnetic nanoparticles are known for different medical applications. The aim of this study is to use an induction heater and magnetic nanoparticles for inducing thermal denaturation. Destroyed tissue structure using the ZVS induction heater and magnetic iron oxide nanoparticles with SHG imaging is presented.

 

We report dynamic imaging of intracellular calcium ion and sarcomere contraction of single cardiomyocytes isolated from adult transgenic zebrafish with multiphoton microscopy. With two-color pseudodynamic 3D imaging, we further reveal the spatiotemporal change of the calcium flow and the cardiac chamber on the beating heart of living zebrafish.

 

The spatial phase demonstrates 0.8 um/(ug/mL) sensitivity in glucose using cascaded optical fiber low-coherence interferometry on the microring resonator (MRR) and surface plasmon resonance (SPR). The MRR sensitivity is the same as highly sensitive SPR and comes from an effective interference length enhanced by its quality factor of 8000.

 

In this study, we demonstrate a simpler platform for label-free biodetection in comparison with the conventional approach entailing sandwiched cells for LC-based biosensing. This unique LC-on-single-substrate technique is capable of rapid screening and bioassay of DNA hybridization.

 

The cornea epithelial layers of rat, rabbit, and human were quantitatively compared. Though the layer thicknesses are comparable (~50 μm), the human cornea has an epithelial cell density about double those of the rat and rabbit. The human Bowman’s layer is also significantly thicker than those of the animals.

 

We proposed a method for identifying early esophageal cancerous lesion by endoscopy and hyperspectral endoscopic imaging. It shows the characteristic spectrum of a normal esophagus, precancerous lesion, canceration, and intraepithelial papillary capillary loop can be identified through principal component score chart. The method enables the accurate visualization of target organs.

 

Collagen is an abundant structural protein in all animals. However, how collagen structurally organized into the functional tissue is still an open question. Here, using the chicken cornea in conjunction with Fast Fourier Transform second harmonic generation microscopy, we investigate the variation at different stage of developing embryos.

 

In this study, we developed a simple method to measure human distal radius bone density based on near infrared (NIR) image system with strong correlation between the optical attenuation and BMD. We hope our NIR bone densitometry may create a new avenue for preventing osteoporosis related fracture in the future.

 

Cancer is a serious disease worldwide. Therefore, precise and personalized treatment of cancer patients is an important frontier of modern medicine. In this study, we use precisely cut tumor slices for drug testing in the mouse model.The technique we demonstrate may be extended for better drug testing in the future.

 

Cyclic immunofluorescence (CycIF) is a procedure in which colours staining alternates with fluorophores’ chemical inactivation. With molecular diffusion, staining becomes a slow process. Therefore, we utilize the alternative electric field to indicate the charged ions movement into depth of tissue and avoid destroying the surface and allow efficient dye penetration.

 

Here we report an automatic approach to efficiently segment Dermal-Epidermal Junction (DEJ) in Optical coherence tomography (OCT) images. In this research, we employ a modified U-Net approach to train semantic segmentation models. The proposed method is evaluated on the test data set with a Dice coefficient of 0.96.

 

We rectified liquid-crystal-based biosensing by introducing a single-substrate structure instead of a sandwich configuration. This technique was applied to detecting the cancer biomarker CA-125 as a demonstration of its feasibility.

 

As a demonstration of clinical relevance using dye-doped liquid crystal as a sensing probe, a label-free immunoassay for the cancer biomarker CA125 was manifested by reacting CA125 with immobilized anti-CA125 antibody.

 

In non-invasive cardiopulmonary exercise testing (CPET), oxygen pulse (O2P) is to the product of stroke volume and oxygen extraction by cells. The patterns in norms, chronic obstructive pulmonary disease (COPD) and heart failure undergo CPET-NIRS measurement. We think it is very potential to early diagnosis cardiopulmonary disease by CPET-NIRS.

 

An HbA1c sensor based on lossy mode resonances (LMRs) technology and optical planar waveguide is presented experimentally. The sensor is a thin-film layer of Indium Tin Oxide (ITO) is deposited. Besides, we design a self-alignment platform for light coupling through optical fiber instead of traditional prism coupling techniques.